Large uncertainty in individual polygenic risk score estimation impacts PRS-based risk stratification-Reference-Cited by-同舟云学术

Large uncertainty in individual polygenic risk score estimation impacts PRS-based risk stratification

Published:2021-12-20 Issue:1 Volume:54 Page:30-39
ISSN:1061-4036
Container-title:Nature Genetics
language:en
Short-container-title:Nat Genet

Author:

Ding Yi^ORCID,Hou Kangcheng^ORCID,Burch Kathryn S.,Lapinska Sandra^ORCID,Privé Florian^ORCID,Vilhjálmsson Bjarni^ORCID,Sankararaman Sriram^ORCID,Pasaniuc Bogdan^ORCID

Funder

U.S. Department of Health & Human Services | National Institutes of Health

Publisher

Springer Science and Business Media LLC

Subject

Genetics

Link

https://www.nature.com/articles/s41588-021-00961-5.pdf

Reference67 articles.

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3. Chatterjee, N., Shi, J. & García-Closas, M. Developing and evaluating polygenic risk prediction models for stratified disease prevention. Nat. Rev. Genet. 17, 392–406 (2016).

4. Sugrue, L. P. & Desikan, R. S. What are polygenic scores and why are they important? JAMA 321, 1820–1821 (2019).

5. Natarajan, P. et al. Polygenic risk score identifies subgroup with higher burden of atherosclerosis and greater relative benefit from statin therapy in the primary prevention setting. Circulation 135, 2091–2101 (2017).

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