Early treatment of SIV+ macaques with an α4β7 mAb alters virus distribution and preserves CD4+ T cells in later stages of infection-Reference-Cited by-同舟云学术

Early treatment of SIV+ macaques with an α4β7 mAb alters virus distribution and preserves CD4+ T cells in later stages of infection

Published:2017-12-20 Issue:3 Volume:11 Page:932-946
ISSN:1933-0219
Container-title:Mucosal Immunology
language:en
Short-container-title:Mucosal Immunol

Author:

Santangelo P J,Cicala C,Byrareddy S N,Ortiz K T,Little D,Lindsay K E,Gumber S,Hong J J,Jelicic K,Rogers K A,Zurla C,Villinger F,Ansari A A,Fauci A S,Arthos J

Publisher

Springer Science and Business Media LLC

Subject

Immunology,Immunology and Allergy

Link

http://www.nature.com/articles/mi2017112.pdf

Reference51 articles.

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2. Heise, C., Miller, C.J., Lackner, A. & Dandekar, S. Primary acute simian immunodeficiency virus infection of intestinal lymphoid tissue is associated with gastrointestinal dysfunction. J Infect Dis 169, 1116–1120 (1994).

3. Mehandru, S. et al. Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract. J Exp Med 200, 761–770 (2004).

4. Veazey, R.S. et al. Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection. Science 280, 427–431 (1998).

5. Brenchley, J.M. et al. CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. J Exp Med 200, 749–759 (2004).

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