Gastrointestinal Tract as a Major Site of CD4 + T Cell Depletion and Viral Replication in SIV Infection-Reference-Cited by-同舟云学术

Gastrointestinal Tract as a Major Site of CD4 + T Cell Depletion and Viral Replication in SIV Infection

Published:1998-04-17 Issue:5362 Volume:280 Page:427-431
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Veazey Ronald S.¹,DeMaria MaryAnn¹,Chalifoux Laura V.¹,Shvetz Daniel E.¹,Pauley Douglas R.¹,Knight Heather L.¹,Rosenzweig Michael¹,Johnson R. Paul¹,Desrosiers Ronald C.¹,Lackner Andrew A.¹

Affiliation:

1. New England Regional Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Post Office Box 9102, Southborough, MA 01772, USA.

Abstract

Human and simian immunodeficiency virus (HIV and SIV) replicate optimally in activated memory CD4 + T cells, a cell type that is abundant in the intestine. SIV infection of rhesus monkeys resulted in profound and selective depletion of CD4 + T cells in the intestine within days of infection, before any such changes in peripheral lymphoid tissues. The loss of CD4 + T cells in the intestine occurred coincident with productive infection of large numbers of mononuclear cells at this site. The intestine appears to be a major target for SIV replication and the major site of CD4 + T cell loss in early SIV infection.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference21 articles.

1. D. D. Ho, et al., Nature 373, 123 (1995); X. Wei et al.,ibid., p. 117; A. Amadori, Zamarchi R., Chieco-Bianchi L., Immunol. Today 17, 414 (1996).

2. T. T. MacDonald and J. Spencer in Gastrointestinal and Hepatic Immunology R. H. Heatley Ed. (Cambridge Univ. Press Cambridge 1994) pp. 1–23.

3. N. Cerf-Bensussan, D. Guy-Grand, Gastroenterol. Clin. N. Am. 20, 549 (1991); Kraehenbuhl J.-P., Neutra M. R., Physiol. Rev. 72, 853 (1992).

4. M. Zeitz, W. C. Greene, N. J. Peffer, S. P. James, Gastroenterology 94, 647 (1988); Schieferdecker H. L., Ullrich R., Hirseland H., Zeitz M., J. Immunol. 149, 2816 (1992).

5. Schneider T., et al., Clin. Exp. Immunol.94, 430 (1994).

Cited by 1242 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Crosstalk between gut microbiome and neuroinflammation in pathogenesis of HIV-associated neurocognitive disorder;Journal of the Neurological Sciences;2024-02

2. A Canadian Survey of Research on HIV-1 Latency—Where Are We Now and Where Are We Heading?;Viruses;2024-02-01

3. Viral Persistence in the Gut-Associated Lymphoid Tissue and Barriers to HIV Cure;AIDS Research and Human Retroviruses;2024-01-01

4. Antibody-mediated depletion of select T cell subsets in blood and tissue of nonhuman primates;2023-12-23

5. Simian immunodeficiency virus and storage buffer: Field-friendly preservation methods for RNA viral detection in primate feces;mSphere;2023-12-20