The IBD interactome: an integrated view of aetiology, pathogenesis and therapy-Reference-Cited by-同舟云学术

The IBD interactome: an integrated view of aetiology, pathogenesis and therapy

Published:2017-08-23 Issue:12 Volume:14 Page:739-749
ISSN:1759-5045
Container-title:Nature Reviews Gastroenterology & Hepatology
language:en
Short-container-title:Nat Rev Gastroenterol Hepatol

Author:

de Souza Heitor S. P.,Fiocchi Claudio,Iliopoulos Dimitrios

Publisher

Springer Science and Business Media LLC

Subject

Gastroenterology,Hepatology

Link

http://www.nature.com/articles/nrgastro.2017.110.pdf

Reference132 articles.

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2. Iyengar, R. Complex diseases require complex therapies. EMBO Rep. 14, 1039–1042 (2013). This insightful commentary highlights the molecular complexity of chronic diseases and suggests that current therapeutic approaches may have reached their limits.

3. Sivakumaran, S. et al. Abundant pleiotropy in human complex diseases and traits. Am. J. Hum. Genet. 89, 607–618 (2011).

4. Ghiassian, S. D. et al. Endophenotype network models: common core of complex diseases. Sci. Rep. 6, 27414 (2016). This article presents an alternative view emphasizing that different diseases often have common underlying mechanisms and shared endophenotypes. The authors construct endophenotype network models and explore their relation to different diseases, identifying critical modules within the subnetworks of the human interactome.

5. de Souza, H. S. & Fiocchi, C. Immunopathogenesis of IBD: current state of the art. Nat. Rev. Gastroenterol. Hepatol. 13, 13–27 (2016). The authors present the current knowledge of the immunity and expand the concept of IBD immunopathogenesis to include various novel components that affect the intestinal inflammatory process.

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