Inhibition of Transmural Inflammation in Crohn’s Disease by Orally Administered Tumor Necrosis Factor-Alpha Deoxyribozymes-Loaded Pyroptosis Nanoinhibitors

Author:

Li Zhun1,Zhu Zhenxing2,Zhou Dongtao3,Chen Yusheng1,Yin Yi4,Zhang Zhibin3,Yang Jingjing5ORCID,Gao Yanfeng6,Zhu Weiming1,Song Yujun3ORCID,Li Yi1

Affiliation:

1. Department of General Surgery, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210023, China

2. Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, China

3. College of Engineering and Applied Sciences, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing 210023, China

4. Department of General Surgery, Affiliated Drum Tower Hospital, Medical School, Nanjing University, Nanjing 210008, China

5. Department of Biochemistry and Molecular Biology, School of Medicine & Holistic Integrative Medicine, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing 210023, China

6. School of Medical Imaging, Wannan Medical College, Wuhu 241002, China

Funder

State Key Laboratory of Analytical Chemistry for Life Sciences

Jiangsu Provincial Key Research and Development Program

National Key Research and Development Program of China

Natural Science Foundation of Jiangsu Province

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

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