Scaling-up Fermentation of Pichia pastoris to demonstration-scale using new methanol-feeding strategy and increased air pressure instead of pure oxygen supplement
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/srep18439.pdf
Reference46 articles.
1. Athmaram, T. N. et al. A simple Pichia pastoris fermentation and downstream processing strategy for making recombinant pandemic Swine Origin Influenza a virus Hemagglutinin protein. J. Ind. Microbio. Biotechnol. 40, 245–255 (2013).
2. Looser, V. et al. Cultivation strategies to enhance productivity of Pichia pastoris: A review. Biotechnol. Adv. 33, 1177–1193 (2015).
3. Potgieter, T. I. et al. Production of monoclonal antibodies by glycoengineered Pichia pastoris. J. Biotechnol. 139, 318–325 (2009).
4. Garcia-Ochoa, F. & Gomez, E. Bioreactor scale-up and oxygen transfer rate in microbial processes: an overview. Biotechnol. Adv. 27, 153–176 (2009).
5. Mate, D. M., Gonzalez-Perez, D., Kittl, R., Ludwig, R. & Alcalde, M. Functional expression of a blood tolerant laccase in Pichia pastoris. BMC Biotechnol. 13, 38–49 (2013).
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