Caveolae: mining little caves for new cancer targets
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Earth and Planetary Sciences,General Environmental Science
Link
http://www.nature.com/articles/nrc1146.pdf
Reference133 articles.
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2. Rothberg, K. G. et al. Caveolin, a protein component of caveolae membrane coats. Cell 68, 673–682 (1992). This paper is one of the first to identify CAV1 as a caveolar-coat protein.
3. Murata, M. et al. VIP21/caveolin is a cholesterol-binding protein. Proc. Natl Acad. Sci. USA 92, 10339–10343 (1995).
4. Schnitzer, J. E., McIntosh, D. P., Dvorak, A. M., Liu, J. & Oh, P. Separation of caveolae from associated microdomains of GPI-anchored proteins. Science 269, 1435–1439 (1995). This paper shows for the first time that caveolae and lipid rafts are biochemically distinct, based on their isolation from two different subcellular fractions derived from the same starting plasma membranes. The subfractionation technology described here makes possible the mapping of tumour-induced endothelial and caveolar targets.
5. Anderson, R. G. & Jacobson, K. A role for lipid shells in targeting proteins to caveolae, rafts, and other lipid domains. Science 296, 1821–1825 (2002).
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