Nanocarrier-based gene delivery for immune cell engineering

Author:

Gharatape Alireza1,Sadeghi-Abandansari Hamid2ORCID,Seifalian Alexander3ORCID,Faridi-Majidi Reza1,Basiri Mohsen45ORCID

Affiliation:

1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

2. Department of Cell Engineering, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Tehran, Iran

3. Nanotechnology & Regenerative Medicine Commercialisation Centre (NanoRegMed Ltd, Nanoloom Ltd, & Liberum Health Ltd), London BioScience Innovation Centre, London, UK

4. Department of Stem Cells and Developmental Biology and Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Tehran, Iran

5. T Cell Therapeutics Research Labs, Cellular Immunotherapy Center, Department of Hematology & Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA

Abstract

Nanocarriers hold great potential for engineering immune cells based on their performance (efficiency, safety and specificity). This review focuses on different stages of the transfection process and some important challenges.

Publisher

Royal Society of Chemistry (RSC)

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