Mechanisms of asymmetric cell division: flies and worms pave the way
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
http://www.nature.com/articles/nrm2388.pdf
Reference150 articles.
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3. Schonegg, S. & Hyman, A. A. CDC-42 and RHO-1 coordinate acto-myosin contractility and PAR protein localization during polarity establishment in C. elegans embryos. Development 133, 3507–3516 (2006).
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5. Jenkins, N., Saam, J. R. & Mango, S. E. CYK-4/GAP provides a localized cue to initiate anteroposterior polarity upon fertilization. Science 313, 1298–1301 (2006). This study reports that the GAP CYK-4 is donated to the zygote by the sperm and is required to initiate establishment of A–P polarity in C. elegans embryos, presumably through local downregulation of Rho activity.
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