Affiliation:
1. Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.
Abstract
The
Caenorhabditis elegans
anteroposterior axis is established in response to fertilization by sperm. Here we present evidence that RhoA, the guanine nucleotide–exchange factor ECT-2, and the Rho guanosine triphosphatase–activating protein CYK-4 modulate myosin light-chain activity to create a gradient of actomyosin, which establishes the anterior domain. CYK-4 is enriched within sperm, and paternally donated CYK-4 is required for polarity. These data suggest that CYK-4 provides a molecular link between fertilization and polarity establishment in the one-cell embryo. Orthologs of CYK-4 are expressed in sperm of other species, which suggests that this cue may be evolutionarily conserved.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
113 articles.
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