The frontline antibiotic vancomycin induces a zinc starvation response in bacteria by binding to Zn(II)

Author:

Zarkan Ashraf,Macklyne Heather-Rose,Truman Andrew W.,Hesketh Andrew R.,Hong Hee-Jeon

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference29 articles.

1. McCormick, M. H. et al. Vancomycin, a new antibiotic. I. Chemical and biologic properties. Antibiot. Annu. 3, 606–611 (1954).

2. Howden, B. P. et al. Reduced vancomycin susceptibility in Staphylococcus aureus, including vancomycin-intermediate and heterogeneous vancomycin-intermediate strains: resistance mechanisms, laboratory detection and clinical implications. Clin. Microbiol. Rev. 23, 99–139 (2010).

3. Rubinstein, E. & Keynan, Y. Vancomycin Revisited–60 years later. Front. Public Health 2, 217 (2014).

4. Hesketh, A. R. & Hong, H. J. Comparative and functional genomics as tools for understanding vancomycin resistance in bacteria. In Vancomycin: Biosynthesis, Clinical Uses and Adverse Effects Nova Science Publishers, New York 19–54 (2013).

5. Hesketh, A. et al. Genome-wide dynamics of bacterial response to antibiotics that target the cell envelope. BMC genomics 12, 226 (2011).

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