In vivo selection with lentiviral expression of Bcl2T69A/S70A/S87A mutant in hematopoietic stem cell-transplanted mice
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics,Molecular Biology,Molecular Medicine
Link
http://www.nature.com/articles/s41434-018-0008-9.pdf
Reference39 articles.
1. Neff T, Horn PA, Valli VE, Gown AM, Wardwell S, Wood BL, et al. Pharmacologically regulated in vivo selection in a large animal. Blood. 2002;100:2026–31.
2. Persons DA, Allay JA, Bonifacino A, Lu T, Agricola B, Metzger ME, et al. Transient in vivo selection of transduced peripheral blood cells using antifolate drug selection in rhesus macaques that received transplants with hematopoietic stem cells expressing dihydrofolate reductase vectors. Blood. 2004;103:796–803.
3. Licht T, Haskins M, Henthorn P, Kleiman SE, Bodine DM, Whitwam T, et al. Drug selection with paclitaxel restores expression of linked IL-2 receptor gamma-chain and multidrug resistance (MDR1) transgenes in canine bone marrow. Proc Natl Acad Sci USA. 2002;99:3123–8.
4. Zhang XB, Beard BC, Trobridge GD, Wood BL, Sale GE, Sud R, et al. High incidence of leukemia in large animals after stem cell gene therapy with a HOXB4-expressing retroviral vector. J Clin Invest. 2008;118:1502–10.
5. Domen J, Cheshier SH, Weissman IL. The role of apoptosis in the regulation of hematopoietic stem cells: overexpression of BCL-2 increases both their number and repopulation potential. J Exp Med. 2000;191:253–64.
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