Metabolic coessentiality mapping identifies C12orf49 as a regulator of SREBP processing and cholesterol metabolism
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Physiology (medical),Endocrinology, Diabetes and Metabolism,Internal Medicine
Link
http://www.nature.com/articles/s42255-020-0206-9.pdf
Reference68 articles.
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2. Pan, J. et al. Interrogation of mammalian protein complex structure, function, and membership using genome-scale fitness screens. Cell Syst. 6, 555–568.e7 (2018).
3. Wainberg, M. et al. A genome-wide almanac of co-essential modules assigns function to uncharacterized genes. Preprint at bioRxiv https://doi.org/10.1101/827071 (2019).
4. Kanehisa, M., Furumichi, M., Tanabe, M., Sato, Y. & Morishima, K. KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 45, D353–D361 (2017).
5. Rozman, J. et al. Identification of genetic elements in metabolism by high-throughput mouse phenotyping. Nat. Commun. 9, 288 (2018).
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