Functional screening and rational design of compounds targeting GPR132 to treat diabetes-Reference-Cited by-同舟云学术

Functional screening and rational design of compounds targeting GPR132 to treat diabetes

Published:2023-09-28 Issue:10 Volume:5 Page:1726-1746
ISSN:2522-5812
Container-title:Nature Metabolism
language:en
Short-container-title:Nat Metab

Author:

Wang Jia-Le,Dou Xiao-Dong^ORCID,Cheng Jie^ORCID,Gao Ming-Xin,Xu Guo-Feng,Ding Wei^ORCID,Ding Jin-Hui,Li Yu^ORCID,Wang Si-Han,Ji Zhao-Wei,Zhao Xin-Yi,Huo Tong-Yu,Zhang Cai-Fang,Liu Ya-Meng,Sha Xue-Ying,Gao Jia-Rui,Zhang Wen-Hui,Hao Yong^ORCID,Zhang Cheng,Sun Jin-Peng^ORCID,Jiao Ning^ORCID,Yu Xiao^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Physiology (medical),Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://www.nature.com/articles/s42255-023-00899-4.pdf

Reference69 articles.

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2. Siehler, J., Blochinger, A. K., Meier, M. & Lickert, H. Engineering islets from stem cells for advanced therapies of diabetes. Nat. Rev. Drug Discov. 20, 920–940 (2021).

3. Talchai, C., Xuan, S., Lin, H. V., Sussel, L. & Accili, D. Pancreatic beta cell dedifferentiation as a mechanism of diabetic beta cell failure. Cell 150, 1223–1234 (2012).

4. Ying, W. et al. Expansion of islet-resident macrophages leads to inflammation affecting beta cell proliferation and function in obesity. Cell Metab. 29, 457–474 (2019).

5. Ying, W., Fu, W., Lee, Y. S. & Olefsky, J. M. The role of macrophages in obesity-associated islet inflammation and β-cell abnormalities. Nat. Rev. Endocrinol. 16, 81–90 (2020).

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