Development of a Potent and Selective G2A (GPR132) Agonist-Reference-Cited by-同舟云学术

Development of a Potent and Selective G2A (GPR132) Agonist

Published:2024-06-25 Issue:13 Volume:67 Page:10567-10588
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hernandez-Olmos Victor¹²^ORCID,Heering Jan¹²,Marinescu Beatrice³,Schermeng Tina⁴^ORCID,Ivanov Vladimir V.⁵,Moroz Yurii S.⁶⁷^ORCID,Nevermann Sheila¹,Mathes Marius³,Ehrler Johanna H. M.³^ORCID,Alnouri Mohamad Wessam⁸,Wolf Markus⁹,Haydo Alicia S.¹⁰,Schmachtel Tessa¹⁰,Zaliani Andrea⁹,Höfner Georg¹¹,Kaiser Astrid³,Schubert-Zsilavecz Manfred³,Beck-Sickinger Annette G.⁴^ORCID,Offermanns Stefan⁸¹²,Gribbon Philipp⁹,Rieger Michael A.⁹¹³¹⁴¹⁵,Merk Daniel¹¹^ORCID,Sisignano Marco¹⁶,Steinhilber Dieter¹²³,Proschak Ewgenij¹²³^ORCID

Affiliation:

1. Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany

2. Fraunhofer Cluster of Excellence Immune-Mediated Diseases CIMD, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany

3. Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Street 9, 60438 Frankfurt am Main, Germany

4. Institute of Biochemistry, Faculty of Life Sciences, Leipzig University, Brüderstraße 34, 04103 Leipzig, Germany

5. Enamine Ltd, 67 Chervonotkatska Street, Kyiv 02094, Ukraine

6. Taras Shevchenko National University of Kyiv, 64 Volodymyrska Street, Kyiv 01601, Ukraine

7. Chemspace LLC, 85 Chervonotkatska Street, Kyiv 02094, Ukraine

8. Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Ludwigstr. 43, 61231Bad Nauheim, Germany

9. Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Discovery Research ScreeningPort, Schnackenburgallee 114, 22525 Hamburg, Germany

10. Department of Medicine, Hematology/Oncology, Goethe University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany

11. Department of Pharmacy, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377 Munich, Germany

12. Center for Molecular Medicine, Goethe University Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany

13. Frankfurt Cancer Institute, 60590 Frankfurt am Main, Germany

14. Cardio-Pulmonary Institute (CPI), 60590 Frankfurt am Main, Germany

15. German Cancer Consortium (DKTK) and German Cancer Research Institute (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

16. Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany

Funder

McGill University

Kungliga Tekniska H?gskolan

Diamond Light Source

Deutsche Forschungsgemeinschaft

Horizon 2020 Framework Programme

European Federation of Pharmaceutical Industries and Associations

Ontario Institute for Cancer Research

Landes-Offensive zur Entwicklung Wissenschaftlich-?konomischer Exzellenz

Fraunhofer Leistungszentrum Innovative Therapeutics

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c02164

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