In vivo screen identifies a SIK inhibitor that induces β cell proliferation through a transient UPR-Reference-Cited by-同舟云学术

In vivo screen identifies a SIK inhibitor that induces β cell proliferation through a transient UPR

Published:2021-05 Issue:5 Volume:3 Page:682-700
ISSN:2522-5812
Container-title:Nature Metabolism
language:en
Short-container-title:Nat Metab

Author:

Charbord Jérémie^ORCID,Ren Lipeng,Sharma Rohit B.,Johansson Anna,Ågren Rasmus,Chu Lianhe,Tworus Dominika,Schulz Nadja,Charbord Pierre,Stewart Andrew F.^ORCID,Wang Peng,Alonso Laura C.^ORCID,Andersson Olov^ORCID

Funder

Vetenskapsrådet

Novo Nordisk Fonden

Diabetesfonden

Ragnar Söderbergs stiftelse

Karolinska Institutet

U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Physiology (medical),Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

http://www.nature.com/articles/s42255-021-00391-x.pdf

Reference82 articles.

1. Chen, C., Cohrs, C. M., Stertmann, J., Bozsak, R. & Speier, S. Human β cell mass and function in diabetes: recent advances in knowledge and technologies to understand disease pathogenesis. Mol. Metab. 6, 943–957 (2017).

2. Zhou, Q. & Melton, D. A. Pancreas regeneration. Nature 557, 351–358 (2018).

3. Wang, P. et al. Combined inhibition of DYRK1A, SMAD, and trithorax pathways synergizes to induce robust replication in adult human β cells. Cell Metab. 29, 638–652 (2019).

4. Wang, P. et al. A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic β cell replication. Nat. Med. 21, 383–388 (2015).

5. El Ouaamari, A. et al. SerpinB1 promotes pancreatic β cell proliferation. Cell Metab. 23, 194–205 (2016).

Cited by 24 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. ER stress relief drives ß-cell proliferation;2024-09-06

2. Targeting β-Cell Plasticity: A Promising Approach for Diabetes Treatment;Current Issues in Molecular Biology;2024-07-18

3. Leveraging zebrafish to investigate pancreatic development, regeneration, and diabetes;Trends in Molecular Medicine;2024-06

4. Select DYRK1A Inhibitors Enhance Both Proliferation and Differentiation in Human Pancreatic Beta Cells;2024-05-17

5. Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity;Nature Metabolism;2024-04-30