Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells-Reference-Cited by-同舟云学术

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Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells

Published:2019-03 Issue:3 Volume:29 Page:638-652.e5
ISSN:1550-4131
Container-title:Cell Metabolism
language:en
Short-container-title:Cell Metabolism

Author:

Wang Peng,Karakose Esra,Liu Hongtao,Swartz Ethan,Ackeifi Courtney,Zlatanic Viktor,Wilson Jessica,González Bryan J.,Bender Aaron,Takane Karen K.,Ye Lillian,Harb George,Pagliuca Felicia,Homann Dirk,Egli Dieter,Argmann Carmen,Scott Donald K.,Garcia-Ocaña Adolfo,Stewart Andrew F.

Funder

Icahn School of Medicine

NIDDK

JDRF

ADA

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Physiology

Reference68 articles.

1. Development of a reliable automated screening system to identify small molecules and biologics that promote human β-cell regeneration;Aamodt;Am. J. Physiol. Endocrinol. Metab.,2016

2. CC-401 promotes β-cell replication via pleiotropic consequences of DYRK1A/B inhibition;Abdolazimi;Endocrinology,2018

3. Combinatorial signal perception in the BMP pathway;Antebi;Cell,2017

4. Targeting the cell cycle inhibitor p57Kip2 promotes adult human β cell replication;Avrahami;J. Clin. Invest.,2014

5. Dyrk1 inhibition improves Alzheimer’s disease-like pathology;Branca;Aging Cell,2017

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3. Development, regeneration, and physiological expansion of functional β-cells: Cellular sources and regulators;Frontiers in Cell and Developmental Biology;2024-07-09

4. Select DYRK1A Inhibitors Enhance Both Proliferation and Differentiation in Human Pancreatic Beta Cells;2024-05-17

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