Accelerating anticancer drug development — opportunities and trade-offs

Author:

Nass Sharyl J.,Rothenberg Mace L.,Pentz Rebecca,Hricak Hedvig,Abernethy Amy,Anderson Kenneth,Gee Amanda Wagner,Harvey R. Donald,Piantadosi Steven,Bertagnolli Monica M.,Schrag Deborah,Schilsky Richard L.

Publisher

Springer Science and Business Media LLC

Subject

Oncology

Reference94 articles.

1. Gan, H. K., You, B., Pond, G. R. & Chen, E. X. Assumptions of expected benefits in randomized phase III trials evaluating systemic treatments for cancer. J. Natl Cancer Inst. 104, 590–598 (2012).

2. Hwang, T. J. et al. Failure of investigational drugs in late-stage clinical development and publication of trial results. JAMA Intern. Med. 176, 1826–1833 (2016).

3. American Association for Cancer Research. AACR cancer progress report 2011. Roswell Park https://www.roswellpark.org/sites/default/files/node-files/asset/nid91575-2011-aacr-cpr-text-web.pdf (2011).

4. Wong, C. H., Siah, K. W. & Lo, A. W. Estimation of clinical trial success rates and related parameters. Biostatistics https://doi.org/10.1093/biostatistics/kxx069 (2018).

5. Dagher, R. et al. Approval summary: imatinib mesylate in the treatment of metastatic and/or unresectable malignant gastrointestinal stromal tumors. Clin. Cancer Res. 8, 3034 (2002).

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