MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C-Reference-Cited by-同舟云学术

MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C

Published:2016-09-15 Issue:1 Volume:7 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Thabet Khaled, ,Asimakopoulos Anastasia,Shojaei Maryam,Romero-Gomez Manuel,Mangia Alessandra,Irving William L.,Berg Thomas,Dore Gregory J.,Grønbæk Henning,Sheridan David,Abate Maria Lorena,Bugianesi Elisabetta,Weltman Martin,Mollison Lindsay,Cheng Wendy,Riordan Stephen,Fischer Janett,Spengler Ulrich,Nattermann Jacob,Wahid Ahmed,Rojas Angela,White Rose,Douglas Mark W.,McLeod Duncan,Powell Elizabeth,Liddle Christopher,van der Poorten David,George Jacob,Eslam Mohammed

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/ncomms12757.pdf

Reference33 articles.

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2. Iredale, J. P. Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ. J. Clin. Invest. 117, 539–548 (2007).

3. Buch, S. et al. A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis. Nat. Genet. 47, 1443–1448 (2015).

4. Mancina, R. M. et al. The MBOAT7-TMC4 variant rs641738 increases risk of nonalcoholic fatty liver disease in individuals of European descent. Gastroenterology 150, 1219–1230.e6 (2016).

5. Masumoto, N. et al. Membrane bound O-acyltransferases and their inhibitors. Biochem. Soc. Trans. 43, 246–252 (2015).

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