Membrane bound O-acyltransferases and their inhibitors-Reference-Cited by-同舟云学术

Membrane bound O-acyltransferases and their inhibitors

Published:2015-04-01 Issue:2 Volume:43 Page:246-252
ISSN:0300-5127
Container-title:Biochemical Society Transactions
language:en
Short-container-title:

Author:

Masumoto Naoko¹²,Lanyon-Hogg Thomas¹,Rodgers Ursula R.³,Konitsiotis Antonios D.³,Magee Anthony I²³,Tate Edward W.¹²

Affiliation:

1. Department of Chemistry, Imperial College London, South Kensington Campus, London, SW7 2AZ, U.K.

2. Institute of Chemical Biology, Department of Chemistry, Imperial College London, SW7 2AZ, U.K.

3. Molecular Medicine Section, National Lung & Heart Institute, Sir Alexander Fleming Building, South Kensington Campus, Imperial College London, SW7 2AZ, U.K.

Abstract

Since the identification of the membrane-bound O-acyltransferase (MBOATs) protein family in the early 2000s, three distinct members [porcupine (PORCN), hedgehog (Hh) acyltransferase (HHAT) and ghrelin O-acyltransferase (GOAT)] have been shown to acylate specific proteins or peptides. In this review, topology determination, development of assays to measure enzymatic activities and discovery of small molecule inhibitors are compared and discussed for each of these enzymes.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Link

https://portlandpress.com/biochemsoctrans/article-pdf/43/2/246/486092/bst0430246.pdf

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