A bioreversible prodrug approach designed to shift mechanism of brain uptake for amino-acid-containing anticancer agents

Author:

Killian Dennis M.,Chikhale Prashant J.

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience,Biochemistry

Reference30 articles.

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2. Selective expression of the large neutral amino acid transporter at the blood-brain barrier;Boado;Proc. Natl Acad. Sci. USA,1999

3. Improved delivery through biological membranes. 4. Prodrugs of l-dopa;Bodor;J. Med. Chem.,1977

4. Junctions between intimately apposed cell membranes in the vertebrate brain;Brightman;J. Cell Biol.,1969

5. The effect of verapamil on the transport of peptides across the blood-brain barrier in rats: kinetic evidence for an apically polarized efflux mechanism;Chikhale;J. Pharmacol. Exp. Ther.,1995a

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