Anti-Spasmogenic Effects of Bencianol (ZY15051 on Human Cerebral Arteries In Vitro

Author:

Whalley ET1,Paul KS1,Gulati OP1

Affiliation:

1. ET Whalley, Department of Pharmacology, the Medical School, University of Manchester, M13 9PT, U.K.; KS Paul, University Department of Neurosurgery, Manchester, U.K.; OP Gulati, Unit of Pharmacology and Biochemistry, Zyma S.A., 1260 Nyon, Switzerland.

Abstract

Experiments were performed to assess the ability of bencianol (ZY15051) to reverse contractions of human basilar arteries in vitro that were induced by a wide range of substances implicated in the aetiology of migraine and cerebral arterial spasm. Bencianol caused a dose-related (1–100 μg ml-1) reversal of contractions induced by 5-hydroxytryptamine, nor-adrenaline, angiotensin II, prostaglandin F2a, and U-46619 (a thromboxane-A2 mimetic). Bencianol was more effective against contractions induced by EC50 compared to maximal concentrations of each agent, and was least effective against the thromboxane-A2 mimetic, U-46619. In addition, contractions induced by thromboxane-A2-like substances generated from guinea-pig lungs were also reversed by bencianol but only at the highest concentration used (100 mg ml-1). The relevance of this action of bencianol to migraine and cerebral arterial spasm is discussed.

Publisher

SAGE Publications

Subject

Neurology (clinical),General Medicine

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