Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil-Reference-Cited by-同舟云学术

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Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil

Published:1999-05 Issue:5 Volume:47 Page:545-552
ISSN:0306-5251
Container-title:British Journal of Clinical Pharmacology
language:en
Short-container-title:British Journal of Clinical Pharmacology

Author:

Tracy Timothy S.¹,Korzekwa Kenneth R.²,Gonzalez Frank J.³,Wainer Irving W.⁴

Affiliation:

1. Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, West Virginia

2. Center for Clinical Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania

3. National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

4. Pharmacokinetics Division, Department of Oncology, McGill University, Montreal, Quebec, Canada

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2125.1999.00923.x

Reference19 articles.

1. The metabolism of DL‐[14C]‐verapamil in man.;Eichelbaum M;Drug Metab Dispos,1979

2. Stereoselective first-pass metabolism of highly cleared drugs: studies of the bioavailability of L- and D-verapamil examined with a stable isotope technique.

3. Identification of P450 enzymes involved in metabolism of verapamil in humans

4. Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans

5. [8] Expression of mammalian cytochrome P450 using vaccinia virus

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