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Quantitative Structure Activity Relationships for the Glucuronidation of Simple Phenols by Expressed Human UGT1A6 and UGT1A9

  • Published:2002-06-01 Issue:6 Volume:30 Page:734-738
  • ISSN:0090-9556
  • Container-title:Drug Metabolism and Disposition
  • language:en
  • Short-container-title:Drug Metab Dispos

Author:

Ethell Brian T.,Ekins Sean,Wang Jibo,Burchell Brian

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference31 articles.

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2. Application of MS-WHIM Descriptors: 1. Introduction of New Molecular Surface Properties and 2. Prediction of Binding Affinity Data

3. Kinetic studies on the metabolism of foreign organic compounds 3. The conjugation of phenols with glucuronic acid.;Bray;Biochem J,1952

4. Studies on the substrate specificity of human intestinal UDP-glucuronosyltransferases 1A8 and 1A10.;Cheng;Drug Metab and Dispos,1999

5. The glucuronidation of opioids, other xenobiotics and androgens by human UGT2B7Y(268) and UGT2B7H(268).;Coffman;Drug Metab and Dispos,1998
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