Novel Bioactivation Mechanism of Reactive Metabolite Formation from Phenyl Methyl-Isoxazoles-Reference-Cited by-同舟云学术

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Novel Bioactivation Mechanism of Reactive Metabolite Formation from Phenyl Methyl-Isoxazoles

Published:2012-08-20 Issue:11 Volume:40 Page:2185-2191
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Bylund Johan,Macsari Istvan,Besidski Yevgeni,Olofsson Susanne,Petersson Carl,Arvidsson Per I.,Bueters Tjerk

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference26 articles.

1. Flucloxacillin-induced liver injury

2. In vitro cytotoxicity as a marker of hypersensitivity to sulphamethoxazole in patients with HIV;Carr;Clin Exp Immunol,1993

3. Targeting voltage-gated sodium channels for pain therapy

4. Comparison of intrinsic metabolic clearance in fresh and cryopreserved human hepatocytes

5. IN VITRO METABOLISM STUDIES ON THE ISOXAZOLE RING SCISSION IN THE ANTI-INFLAMMATORY AGENT LEFLUNOMIDE TO ITS ACTIVE α-CYANOENOL METABOLITE A771726: MECHANISTIC SIMILARITIES WITH THE CYTOCHROME P450-CATALYZED DEHYDRATION OF ALDOXIMES

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