Biotransformation of Two β-Secretase Inhibitors Including Ring Opening and Contraction of a Pyrimidine Ring-Reference-Cited by-同舟云学术

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Biotransformation of Two β-Secretase Inhibitors Including Ring Opening and Contraction of a Pyrimidine Ring

Published:2013-03-08 Issue:5 Volume:41 Page:1134-1147
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Lindgren Anders,Eklund Göran,Turek Dominika,Malmquist Jonas,Swahn Britt-Marie,Holenz Jörg,von Berg Stefan,Karlström Sofia,Bueters Tjerk

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference32 articles.

1. Effect of Solvents on the Time-Dependent Inhibition of CYP3A4 and the Biotransformation of AZD3839 in Human Liver Microsomes and Hepatocytes

2. Rates of metabolism of chlorzoxazone, dextromethorphan, 7-ethoxycoumarin, imipramine, quinidine, testosterone and verapamil by fresh and cryopreserved rat liver slices, and some comparisons with microsomes

3. Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor

4. Comparison of intrinsic metabolic clearance in fresh and cryopreserved human hepatocytes

5. P4‐196: The novel BACE inhibitor MK‐8931 dramatically lowers cerebrospinal fluid Aβ peptides in healthy subjects following single‐ and multiple‐dose administration

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1. 6H-Pyrimido[2,1-a]isoindoles: acid–base and complexation properties and electrooxidation model of metabolic degradation;Monatshefte für Chemie - Chemical Monthly;2023-05-13

2. High-resolution mass spectrometry-based data acquisition and data-mining technologies for detecting and characterizing drug metabolites and traditional Chinese medicine components;Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters;2020

3. The Organocatalytic Approach to Enantiopure 2H- and 3H-Pyrroles: Inhibitors of the Hedgehog Signaling Pathway;Angewandte Chemie International Edition;2016-05-30

4. Organokatalytische Synthese von enantiomerenreinen 2H- und 3H-Pyrrolen: Inhibitoren des Hedgehog-Signalwegs;Angewandte Chemie;2016-05-30

5. Optimizing DMPK Properties: Experiences from a Big Pharma DMPK Department;Current Drug Metabolism;2016-02-12

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