Mechanistic Modeling to Predict Midazolam Metabolite Exposure from In Vitro Data-Reference-Cited by-同舟云学术

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Mechanistic Modeling to Predict Midazolam Metabolite Exposure from In Vitro Data

Published:2016-03-08 Issue:5 Volume:44 Page:781-791
ISSN:1521-009X
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metabolism and Disposition

Author:

Nguyen H. Q.,Kimoto E.,Callegari E.,Obach R. S.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference61 articles.

1. Solubility and acid—base behaviour of midazolam in media of different pH, studied by ultraviolet spectrophotometry with multicomponent software

2. Predicting Circulating Human Metabolites: How Good Are We?

3. The area under the plasma concentration-time curve for oral midazolam is 400-fold larger during treatment with itraconazole than with rifampicin

4. Drug Metabolites in Safety Testing

5. Scaling Factors for the Extrapolation of In Vivo Metabolic Drug Clearance From In Vitro Data: Reaching a Consensus on Values of Human Micro-somal Protein and Hepatocellularity Per Gram of Liver

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