Physiologically Based Pharmacokinetic Modeling to Predict the Impact of Liver Cirrhosis on Glucuronidation via UGT1A4 and UGT2B7/2B4—A Case Study with Midazolam-Reference-Cited by-同舟云学术

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Physiologically Based Pharmacokinetic Modeling to Predict the Impact of Liver Cirrhosis on Glucuronidation via UGT1A4 and UGT2B7/2B4—A Case Study with Midazolam

Published:2024-04-23 Issue:7 Volume:52 Page:614-625
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Ozbey Agustos C.^ORCID,Keemink Janneke,Wagner Bjoern,Pugliano Alessandra,Krähenbühl Stephan^ORCID,Annaert Pieter^ORCID,Fowler Stephen^ORCID,Parrott Neil,Umehara Kenichi

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Reference44 articles.

1. Midazolam kinetics;Allonen;Clin Pharmacol Ther,1981

2. Effect of changes in metabolic enzymes and transporters on drug metabolism in the context of liver disease: Impact on pharmacokinetics and drug-drug interactions;Armani;Br J Clin Pharmacol,2024

3. Severity of cirrhosis and the relationship of α 1-acid glycoprotein concentration to plasma protein binding of lidocaine;Barry;Clin Pharmacol Ther,1990

4. Nuclear receptors and endobiotics glucuronidation: the good, the bad, and the UGT

5. Portal Hypertension: Pathophysiology, Diagnosis, and Treatment

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