MECHANISM-BASED INACTIVATION AND REVERSIBILITY: IS THERE A NEW TREND IN THE INACTIVATION OF CYTOCHROME P450 ENZYMES?
Author:
Publisher
American Society for Pharmacology & Experimental Therapeutics (ASPET)
Subject
Pharmaceutical Science,Pharmacology
Reference42 articles.
1. Reaction of Monosubstituted Hydrazines and Diazenes with Rat-Liver Cytochrome P450. Formation of Ferrous-Diazene and Ferric sigma-Alkyl Complexes
2. P450 Active Site Architecture and Reversibility: Inactivation of Cytochromes P450 2B4 and 2B4 T302A by tert-Butyl Acetylenes
3. Mechanism-Based Inactivation of Cytochromes P450 2E1 and 2E1 T303A by tert-Butyl Acetylenes: Characterization of Reactive Intermediate Adducts to the Heme and Apoprotein
4. Novel Reversible Inactivation of Cytochrome P450 2E1 T303A bytert-Butyl Acetylene: The Role of Threonine 303 in Proton Delivery to the Active Site of Cytochrome P450 2E1
5. Formation of a Novel Reversible Cytochrome P450 Spectral Intermediate: Role of Threonine 303 in P450 2E1 Inactivation
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