Characterization of in Vitro Biotransformation of New, Orally Active, Direct Thrombin Inhibitor Ximelagatran, an Amidoxime and Ester Prodrug

Author:

Clement Bernd,Lopian Katrin

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference33 articles.

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3. Clement B (1993) Methoden zur Behandlung und Prophylaxe der Pneumocystis carinii pneumonie (PCP) und anderen Erkrankungen sowie Verbindungen und Formulierungen zum Gebrauch bei besagten Methoden. German patent, P 4321444.4, PCT/DE 94/00756(1994); USA (5, 786, 383;28/6/1998); Europe (0708640, 16/9/1998).

4. REDUCTION OFN-HYDROXYLATED COMPOUNDS: AMIDOXIMES (N-HYDROXYAMIDINES) AS PRO-DRUGS OF AMIDINES

5. Microsomal Catalyzed N-Hydroxylation of Guanabenz and Reduction of the N-Hydroxylated Metabolite:  Characterization of the Two Reactions and Genotoxic Potential of Guanoxabenz1

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