Unexpected Mexiletine Responses of a Mutant Cardiac Na+ Channel Implicate the Selectivity Filter as a Structural Determinant of Antiarrhythmic Drug Access-Reference-Cited by-同舟云学术

Unexpected Mexiletine Responses of a Mutant Cardiac Na+ Channel Implicate the Selectivity Filter as a Structural Determinant of Antiarrhythmic Drug Access

Published:2004-07-20 Issue:2 Volume:66 Page:330-336
ISSN:0026-895X
Container-title:Molecular Pharmacology
language:en
Short-container-title:Mol Pharmacol

Author:

Sasaki Koji,Makita Naomasa,Sunami Akihiko,Sakurada Harumizu,Shirai Nobumasa,Yokoi Hisataka,Kimura Akinori,Tohse Noritsugu,Hiraoka Masayasu,Kitabatake Akira

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference30 articles.

1. A novelSCN5Amutation associated with idiopathic ventricular fibrillation without typical ECG findings of Brugada syndrome

2. Lidocaine block of cardiac sodium channels.

3. Sodium Channel Blockers Identify Risk for Sudden Death in Patients With ST-Segment Elevation and Right Bundle Branch Block but Structurally Normal Hearts

4. From Ionic Currents to Molecular Mechanisms

Cited by 71 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Structural basis for inhibition of the cardiac sodium channel by the atypical antiarrhythmic drug ranolazine;Nature Cardiovascular Research;2023-05-04

2. Molecular Modeling of Cardiac Sodium Channel with Mexiletine;Membranes;2022-12-10

3. Effects of Mexiletine on a Race-specific Mutation in Nav1.5 Associated With Long QT Syndrome;Frontiers in Physiology;2022-07-05

4. Identification of NVP-CLR457 as an Orally Bioavailable Non-CNS-Penetrant pan-Class IA Phosphoinositol-3-Kinase Inhibitor;Journal of Medicinal Chemistry;2022-05-02

5. Pharmacokinetics‐On‐a‐Chip: In Vitro Microphysiological Models for Emulating of Drugs ADME;Advanced Biology;2021-07-29