Structural basis for inhibition of the cardiac sodium channel by the atypical antiarrhythmic drug ranolazine

Author:

Lenaeus MichaelORCID,Gamal El-Din Tamer M.ORCID,Tonggu LigeORCID,Zheng NingORCID,Catterall William A.ORCID

Funder

U.S. Department of Health & Human Services | National Institutes of Health

Howard Hughes Medical Institute

Publisher

Springer Science and Business Media LLC

Reference47 articles.

1. Hall, A. E., Hutter, O. F. & Noble, D. Current–voltage relations of Purkinje fibres in sodium-deficient solutions. J. Physiol. 166, 2225–2240 (1963).

2. McAllister, R. E., Noble, D. & Tsien, R. W. Reconstruction of the electrical activity of cardiac Purkinje fibres. J. Physiol. 251, 1–59 (1975).

3. Fozzard, H. A. & Hanck, D. A. Structure and function of voltage-dependent sodium channels: comparison of brain II and cardiac isoforms. Physiol. Rev. 76, 887–926 (1996).

4. Catterall, W. A. & Lenaeus, M. J. in Cardiac Electrophysiology: From Cell to Bedside (eds Jalife, J. et al.) Ch. 1 (Elsevier, 2022).

5. Sampson, K. J. & Kass, R. K. in Goodman & Gilman’s Pharmacological Basis of Therapeutics 12th edn (eds Brunton, L. et al.) 815–848 (McGraw-Hill Education/Medical, 2011).

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