Potential Contribution of Cytochrome P450 2B6 to Hepatic 4-Hydroxycyclophosphamide Formation In Vitro and In Vivo-Reference-Cited by-同舟云学术

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Potential Contribution of Cytochrome P450 2B6 to Hepatic 4-Hydroxycyclophosphamide Formation In Vitro and In Vivo

Published:2011-10-05 Issue:1 Volume:40 Page:54-63
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Raccor Brianne S.,Claessens Adam J.,Dinh Jean C.,Park Julie R.,Hawkins Douglas S.,Thomas Sushma S.,Makar Karen W.,McCune Jeannine S.,Totah Rheem A.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference39 articles.

1. Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450-2b and P450-3a in human liver microsomes;Chang;Cancer Res,1993

2. Rabbit CYP4B1 engineered for high-level expression in Escherichia coli: ligand stabilization and processing of the N-terminus and heme prosthetic group

3. Clinical Pharmacokinetics of Cyclophosphamide

4. Effects of co-medicated drugs on cyclophosphamide bioactivation in human liver microsomes

5. Influence of polymorphisms of drug metabolizing enzymes (CYP2B6, CYP2C9, CYP2C19, CYP3A4, CYP3A5, GSTA1, GSTP1, ALDH1A1 and ALDH3A1) on the pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide

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