An Unusual Metabolic Pathway of Sipoglitazar, a Novel Antidiabetic Agent: Cytochrome P450-Catalyzed Oxidation of Sipoglitazar Acyl Glucuronide-Reference-Cited by-同舟云学术

An Unusual Metabolic Pathway of Sipoglitazar, a Novel Antidiabetic Agent: Cytochrome P450-Catalyzed Oxidation of Sipoglitazar Acyl Glucuronide

Published:2011-10-25 Issue:2 Volume:40 Page:249-258
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Nishihara Mitsuhiro,Sudo Miyako,Kawaguchi Naohiro,Takahashi Junzo,Kiyota Yutaka,Kondo Takahiro,Asahi Satoru

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference22 articles.

1. Benzylic Oxidation of Gemfibrozil-1-O-β-Glucuronide by P450 2C8 Leads to Heme Alkylation and Irreversible Inhibition

2. CYTOCHROME P450-MEDIATED OXIDATION OF GLUCURONIDE DERIVATIVES: EXAMPLE OF ESTRADIOL-17β-GLUCURONIDE OXIDATION TO 2-HYDROXY-ESTRADIOL-17β-GLUCURONIDE BY CYP 2C8

3. pH-dependent rearrangement of the biosynthetic ester glucuronide of valproic acid to β-glucuronidase-resistant forms;Dickinson;Drug Metab Dispos,1984

4. Effect of pH on acyl migration and hydrolysis of tolmetin glucuronide;Hyneck;Drug Metab Dispos,1988

5. Structural diversity of human xenobiotic-metabolizing cytochrome P450 monooxygenases

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Interplay of UDP-Glucuronosyltransferase and CYP2C8 for CYP2C8 Mediated Drug Oxidation and Its Impact on Drug–Drug Interaction Produced by Standardized CYP2C8 Inhibitors, Clopidogrel and Gemfibrozil;Clinical Pharmacokinetics;2023-11-03

2. Acyl glucuronides–mediators of drug-induced toxicities?;Medicinal Chemistry Research;2023-04-24

3. Comparative analysis of CYP2C8-medidated drug-drug interactions produced by CYP2C8 inhibitors, gemfibrozil versus clopidogrel, focusing on the inhibition of drug distribution in UDP-glucuronosyltransferase prior to oxidation;2023-01-09

4. Construction of a fused grid-based CYP2C8-Template system and the application;Drug Metabolism and Pharmacokinetics;2023-01

5. In Vitro Evidence of Potential Interactions between CYP2C8 and Candesartan Acyl-β-D-glucuronide in the Liver;Drug Metabolism and Disposition;2021-01-14