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Quinidine and Haloperidol as Modifiers of CYP3A4 Activity: Multisite Kinetic Model Approach

  • Published:2002-12-01 Issue:12 Volume:30 Page:1512-1522
  • ISSN:0090-9556
  • Container-title:Drug Metabolism and Disposition
  • language:en
  • Short-container-title:Drug Metab Dispos

Author:

Galetin Aleksandra,Clarke Stephen E.,Houston J. Brian

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference38 articles.

1. Dual role of human cytochrome P450 3A4 residue Phe-304 in substrate specificity and cooperativity.;Domanski;J Pharmacol Exp Ther,2000

2. Phenylalanine and Tryptophan Scanning Mutagenesis of CYP3A4 Substrate Recognition Site Residues and Effect on Substrate Oxidation and Cooperativity

3. Metabolism of fentanyl, a synthetic opioid analgesic, by human liver microsomes.;Feierman;Drug Metab Dispos,1996

4. Analysis of human cytochrome P450 3A4 cooperativity: Construction and characterization of a site-directed mutant that displays hyperbolic steroid hydroxylation kinetics

5. Elucidation of Distinct Ligand Binding Sites for Cytochrome P450 3A4
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