Therapeutic Neuroprotection by an Engineered Neurotrophin that Selectively Activates Tropomyosin Receptor Kinase (Trk) Family Neurotrophin Receptors but Not the p75 Neurotrophin Receptor-Reference-Cited by-同舟云学术

Therapeutic Neuroprotection by an Engineered Neurotrophin that Selectively Activates Tropomyosin Receptor Kinase (Trk) Family Neurotrophin Receptors but Not the p75 Neurotrophin Receptor

Published:2021-08-31 Issue:5 Volume:100 Page:491-501
ISSN:0026-895X
Container-title:Molecular Pharmacology
language:en
Short-container-title:Mol Pharmacol

Author:

Brahimi Fouad,Galan Alba,Siegel Sairey,Szobota Stephanie,Sarunic Marinko V.,Foster Alan C.,Saragovi H. Uri

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference42 articles.

1. Ligand-Dependent TrkA Activity in Brain Differentially Affects Spatial Learning and Long-Term Memory

2. Chronic and Acute Models of Retinal Neurodegeneration TrkA Activity Are Neuroprotective whereas p75NTR Activity Is Neurotoxic through a Paracrine Mechanism

3. An Agonistic TrkB mAb Causes Sustained TrkB Activation, Delays RGC Death, and Protects the Retinal Structure in Optic Nerve Axotomy and in Glaucoma

4. The route of administration influences the therapeutic index of an anti-proNGF neutralizing mAb for experimental treatment of diabetic retinopathy;Barcelona;PLoS One,2018

5. A Pro-Nerve Growth Factor (proNGF) and NGF Binding Protein, α 2 -Macroglobulin, Differentially Regulates p75 and TrkA Receptors and Is Relevant to Neurodegeneration Ex Vivo and In Vivo

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1. The Use of Neurotrophic Factors as a Promising Strategy for the Treatment of Neurodegenerative Diseases (Review);Bulletin of Experimental Biology and Medicine;2024-09-12

2. TrkB transmembrane domain: bridging structural understanding with therapeutic strategy;Trends in Biochemical Sciences;2024-05

3. The efficacy of a TrkB monoclonal antibody agonist in preserving the auditory nerve in deafened guinea pigs;Hearing Research;2023-11

4. A, B, C’s of Trk Receptors and Their Ligands in Ocular Repair;International Journal of Molecular Sciences;2022-11-15

5. A neurotrophic approach to treating hearing loss: Translation from animal models to clinical proof-of-concept;The Journal of the Acoustical Society of America;2022-06