Metabolism, Pharmacokinetics, and Excretion of the Substance P Receptor Antagonist CP-122,721 in Humans: Structural Characterization of the Novel Major Circulating Metabolite 5-Trifluoromethoxy Salicylic Acid by High-Performance Liquid Chromatography-Tandem Mass Spectrometry and NMR Spectroscopy-Reference-Cited by-同舟云学术

Metabolism, Pharmacokinetics, and Excretion of the Substance P Receptor Antagonist CP-122,721 in Humans: Structural Characterization of the Novel Major Circulating Metabolite 5-Trifluoromethoxy Salicylic Acid by High-Performance Liquid Chromatography-Tandem Mass Spectrometry and NMR Spectroscopy

Published:2007-03-14 Issue:6 Volume:35 Page:884-897
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Colizza Kevin,Awad Mohamed,Kamel Amin

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference14 articles.

1. Mass spectral analysis of glucuronides

2. Colizza K and Kamel A (2004) Characterization of in vivo metabolites of the potent tachykinin NK1 receptor antagonist, CP-122,721 in Humans by HPLC/RAM/ESI/MS/MS, in The 52nd American Society for Mass Spectrometry (ASMS) Conference on Mass Spectrometry and Allied Topics, Nashville, TN, 23-27 May, 2004. American Society for Mass Spectrometry, Santa Fe.

3. Correlation of Neurokinin (NK) 1 Receptor Occupancy in Gerbil Striatum with Behavioral Effects of NK1 Antagonists

4. Determination of mean valproic acid serum level by assay of a single pooled sample

5. Substance P Receptor Antagonists in Psychiatry

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