Strategies for the Identification of Unusual and Novel Metabolites Using Derivatization, Hydrogen-deuterium Exchange (HDX), and Liquid Chromatography-nuclear Magnetic Resonance (LC-NMR) Spectroscopy Techniques

Author:

Kamel Amin1,Harriman Shawn1,Prakash Chandra2

Affiliation:

1. Novartis Institutes for BioMedical Research, Inc.; Cambridge MA USA

2. Biogen Idec, Inc.; Cambridge MA USA

Publisher

John Wiley & Sons, Ltd

Reference79 articles.

1. High-throughput screening in drug metabolism and pharmacokinetic support of drug discovery;White;Annu. Rev. Pharmacol. Toxicol.,2000

2. The influence of DMPK as an integrated partner in modern drug discovery;Riley;Curr. Drug. Metab.,2002

3. Do drug metabolism and pharmacokinetic departments make any contribution to drug discovery?;Smith;Clin. Pharmacokinet.,2002

4. The pivotal role of drug metabolism and pharmacokinetics in the discovery and development of new medicines;Alavijeh;Invest. Drugs.,2004

5. Discovering drugs through biological transformation: role of pharmacologically active metabolites in drug discovery;Fura;J. Med. Chem.,2004

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