Extending a Systems Model of the APP Pathway: Separation of β- and γ-Secretase Sequential Cleavage Steps of APP-Reference-Cited by-同舟云学术

Extending a Systems Model of the APP Pathway: Separation of β- and γ-Secretase Sequential Cleavage Steps of APP

Published:2018-03-21 Issue:3 Volume:365 Page:507-518
ISSN:0022-3565
Container-title:Journal of Pharmacology and Experimental Therapeutics
language:en
Short-container-title:J Pharmacol Exp Ther

Author:

van Maanen Eline M. T.,van Steeg Tamara J.,Ahsman Maurice J.,Michener Maria S.,Savage Mary J.,Kennedy Matthew E.,Kleijn Huub Jan,Stone Julie,Danhof Meindert

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

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2. The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

3. The Basic Biology of BACE1: A Key Therapeutic Target for Alzheimers Disease

4. Acute -Secretase Inhibition of Nonhuman Primate CNS Shifts Amyloid Precursor Protein (APP) Metabolism from Amyloid- Production to Alternative APP Fragments without Amyloid- Rebound

5. BMS-708,163 Targets Presenilin and Lacks Notch-Sparing Activity

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