BMS-708,163 Targets Presenilin and Lacks Notch-Sparing Activity-Reference-Cited by-同舟云学术

BMS-708,163 Targets Presenilin and Lacks Notch-Sparing Activity

Published:2012-09-04 Issue:37 Volume:51 Page:7209-7211
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Crump Christina J.¹²,Castro Suita V.²,Wang Feng²,Pozdnyakov Nikolay³,Ballard T. Eric³,Sisodia Sangram S.⁴,Bales Kelly R.³,Johnson Douglas S.³,Li Yue-Ming¹²

Affiliation:

1. Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, United States

2. Department of Pharmacology, Weill Graduate School of Medical Sciences of Cornell University, New York, New York 10021, United States

3. Pfizer Worldwide Research and Development, 700 Main Street, Cambridge, Massachusetts 02139, United States

4. The Center for Molecular Neurobiology, The University of Chicago, 947 East 58th Street, MC 0926, Chicago, Illinois 60637, United States

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi301137h

Reference19 articles.

1. The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

2. Loss of presenilin 1 is associated with enhanced -catenin signaling and skin tumorigenesis

3. Notch1 functions as a tumor suppressor in mouse skin

4. Eli Lilly and Co.http://newsroom.lilly.com/releasedetail.cfm?releaseid=499794, August 17, 2010.

5. Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor

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