Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor-Reference-Cited by-同舟云学术

Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor

Published:2010-03-22 Issue:3 Volume:1 Page:120-124
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Gillman Kevin W.¹,Starrett John E.¹,Parker Michael F.¹,Xie Kai¹,Bronson Joanne J.¹,Marcin Lawrence R.¹,McElhone Kate E.¹,Bergstrom Carl P.¹,Mate Robert A.¹,Williams Richard²,Meredith Jere E.³,Burton Catherine R.³,Barten Donna M.³,Toyn Jeremy H.³,Roberts Susan B.³,Lentz Kimberley A.⁴,Houston John G.³,Zaczek Robert³,Albright Charles F.³,Decicco Carl P.¹,Macor John E.¹,Olson Richard E.¹

Affiliation:

1. Neuroscience Discovery Chemistry, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492

2. Medicinal Chemistry Department, Albany Molecular Research Incorporated, 26 Corporate Circle, Albany, New York 15098

3. Neuroscience Discovery Biology, Bristol-Myers Squibb, 5 Research Parkway, Wallingford, Connecticut 06492

4. Metabolism and Pharmacokinetics, Bristol-Myers Squibb, 5 Research Parkway, Wallingford, Connecticut 06492

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml1000239

Reference22 articles.

1. Deciphering the Molecular Basis of Memory Failure in Alzheimer's Disease

2. Alzheimer's Disease: Genes, Proteins, and Therapy

3. Dynamics of β-Amyloid Reductions in Brain, Cerebrospinal Fluid, and Plasma of β-Amyloid Precursor Protein Transgenic Mice Treated with a γ-Secretase Inhibitor

4. Studies on the pharmacokinetics and metabolism of a γ-secretase inhibitor BMS-299897, and exploratory investigation of CYP enzyme induction

5. Discovery of Begacestat, a Notch-1-Sparing γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease

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