PROTEIN COVALENT BINDING OF MAXIPOST THROUGH A CYTOCHROME P450-MEDIATED ORTHO-QUINONE METHIDE INTERMEDIATE IN RATS-Reference-Cited by-同舟云学术

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PROTEIN COVALENT BINDING OF MAXIPOST THROUGH A CYTOCHROME P450-MEDIATED ORTHO-QUINONE METHIDE INTERMEDIATE IN RATS

Published:2003-07 Issue:7 Volume:31 Page:837-845
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Zhang Donglu,Ogan Marc,Gedamke Richard,Roongta Vikram,Dai Renke,Zhu Mingshe,Rinehart J. Kent,Klunk Lewis,Mitroka James

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference44 articles.

1. Evidence That 4-Allyl-o-quinones Spontaneously Rearrange to Their More Electrophilic Quinone Methides: Potential Bioactivation Mechanism for the Hepatocarcinogen Safrole

2. The influence of 4-alkyl substituents on the formation and reactivity of 2-methoxy-quinone methides: evidence that extended π-conjugation dramatically stabilizes the quinone methide formed from eugenol

3. Influence of quinone methide reactivity on the alkylation of thiol and amino groups in proteins: studies utilizing amino acid and peptide models

4. The enzymic formation and chemical reactivity of quinone methides correlate with alkylphenol-induced toxicity in rat hepatocytes

5. Development of an in Vitro Screening Model for the Biosynthesis of Acyl Glucuronide Metabolites and the Assessment of Their Reactivity toward Human Serum Albumin

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1. The Importance of Tracking “Missing” Metabolites: How and Why?;Journal of Medicinal Chemistry;2023-09-28

2. Reactive Electrophiles and Metabolic Activation;Reference Module in Biomedical Sciences;2023

3. Metabolic and Pharmaceutical Aspects of Fluorinated Compounds;Journal of Medicinal Chemistry;2020-03-17

4. The Synthesis and Use of BMS 204352 (MaxiPostTM);Mini-Reviews in Organic Chemistry;2020-01-27

5. Cytotoxicity of safrole in HepaRG cells: studies on the role of CYP1A2-mediated ortho-quinone metabolic activation;Xenobiotica;2019-06-19

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