Potent Mechanism-Based Inhibition of Human CYP2B6 by Clopidogrel and Ticlopidine-Reference-Cited by-同舟云学术

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Potent Mechanism-Based Inhibition of Human CYP2B6 by Clopidogrel and Ticlopidine

Published:2003-10-16 Issue:1 Volume:308 Page:189-197
ISSN:0022-3565
Container-title:Journal of Pharmacology and Experimental Therapeutics
language:en
Short-container-title:J Pharmacol Exp Ther

Author:

Richter Tanja,Mürdter Thomas E.,Heinkele Georg,Pleiss Jürgen,Tatzel Stephan,Schwab Matthias,Eichelbaum Michel,Zanger Ulrich M.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmacology,Molecular Medicine

Reference41 articles.

1. Regioselectivity of CYP2B6: homology modeling, molecular dynamics simulation, docking

2. Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug.

3. Cytochrome P-450 2B6 Is Responsible for Interindividual Variability of Propofol Hydroxylation by Human Liver Microsomes

4. Inactivation of the human P2Y12 receptor by thiol reagents requires interaction with both extracellular cysteine residues, Cys17 and Cys270

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