A Two-Tiered In Vitro Approach to De-Risk Drug Candidates for Potential Bile Salt Export Pump Inhibition Liabilities in Drug Discovery-Reference-Cited by-同舟云学术

登录注册会员服务联系我们

A Two-Tiered In Vitro Approach to De-Risk Drug Candidates for Potential Bile Salt Export Pump Inhibition Liabilities in Drug Discovery

Published:2020-09-17 Issue:11 Volume:48 Page:1147-1160
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Hafey Michael J.,Houle Robert,Tanis Keith Q.,Knemeyer Ian,Shang Jackie,Chen Qing,Baudy Andreas,Monroe James,Sistare Frank D.,Evers Raymond

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference45 articles.

1. Intrahepatic cholestasis: Summary of an American Association for the Study of Liver Diseases single-topic conference

2. OSTα-OSTβ: A major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia

3. In Vitro Methods to Support Transporter Evaluation in Drug Discovery and Development

4. Early Alterations of Bile Canaliculi Dynamics and the Rho Kinase/Myosin Light Chain Kinase Pathway Are Characteristics of Drug-Induced Intrahepatic Cholestasis

5. Improving prediction of metabolic clearance using quantitative extrapolation of results obtained from human hepatic micropatterned cocultures model and by considering the impact of albumin binding;Da-Silva;J Pharm Sci,2018

Cited by 13 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Impact of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) on the expression and function of hepatobiliary transporters: A comprehensive mechanistic review;Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease;2024-03

2. Membrane transporters in drug development and as determinants of precision medicine;Nature Reviews Drug Discovery;2024-01-24

3. Hepatic Bile Acid Transporters and Drug-induced Hepatotoxicity;Toxicologic Pathology;2023-11-20

4. DRUG-INDUCED LIVER INJURY: MECHANISMS, METHODS FOR PRE-CLINICAL ASSESSMENT, AND A MEDICINAL CHEMIST’S PERSPECTIVE;Medicinal Chemistry Reviews;2023-11-16

5. Molecular and Clinical Links between Drug-Induced Cholestasis and Familial Intrahepatic Cholestasis;International Journal of Molecular Sciences;2023-03-18

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号京ICP备18003416号-3