Revisiting Nonlinear Bosentan Pharmacokinetics by Physiologically Based Pharmacokinetic Modeling: Target Binding, Albeit Not a Major Contributor to Nonlinearity, Can Offer Prediction of Target Occupancy-Reference-Cited by-同舟云学术

Revisiting Nonlinear Bosentan Pharmacokinetics by Physiologically Based Pharmacokinetic Modeling: Target Binding, Albeit Not a Major Contributor to Nonlinearity, Can Offer Prediction of Target Occupancy

Published:2021-02-08 Issue:4 Volume:49 Page:298-304
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Koyama Satoshi^ORCID,Toshimoto Kota,Lee Wooin^ORCID,Aoki Yasunori,Sugiyama Yuichi

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference18 articles.

1. Aoki Y Hayami K Toshimoto K Sugiyama Y (2020) Cluster Gauss–Newton method: an algorithm for finding multiple approximate minimisers of nonlinear least squares problems with applications to parameter estimation of pharmacokinetic models. Optim Eng DOI: 10.1007/s11081-020-09571-2.

2. PopED lite: an optimal design software for preclinical pharmacokinetic and pharmacodynamic studies;Aoki;Comput Methods Programs Biomed,2016

3. Phase 0/microdosing approaches: time for mainstream application in drug development?;Burt;Nat Rev Drug Discov,2020

4. Influence of Food Intake and Formulation on the Pharmacokinetics and Metabolism of Bosentan, a Dual Endothelin Receptor Antagonist

Cited by 11 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. When to consider intra-target microdosing: physiologically based pharmacokinetic modeling approach to quantitatively identify key factors for observing target engagement;Frontiers in Pharmacology;2024-07-25

2. Beyond the basics: A deep dive into parameter estimation for advanced PBPK and QSP models;Drug Metabolism and Pharmacokinetics;2024-06

3. Elucidating nonlinear pharmacokinetics of telmisartan: Integration of target‐mediated drug disposition and OATP1B3‐mediated hepatic uptake in a physiologically based model;CPT: Pharmacometrics & Systems Pharmacology;2024-05-14

4. After 50 Years of Hepatic Clearance Models, Where Should We Go from Here? Improvements and Implications for Physiologically Based Pharmacokinetic Modeling;Drug Metabolism and Disposition;2024-05-08

5. Kinetic modeling of the plasma pharmacokinetic profiles of ADAMTS13 fragment and its Fc-fusion counterpart in mice;Frontiers in Pharmacology;2024-03-25