Prediction of Human Disproportionate and Biliary Excreted Metabolites Using Chimeric Mice with Humanized Liver

Author:

Kato Suguru,Shah Abhi,Plesescu Mihaela,Miyata Yoshinari,Bolleddula Jayaprakasam,Chowdhury Swapan,Zhu Xiaochun

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference39 articles.

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2. Predicting Circulating Human Metabolites: How Good Are We?

3. Bishop WR Doll RJ Mallams AK Njoroge FG Petrin JM Piwinski JJ Wolin RL Taveras AG Remiszewski SW (1998) Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases. U.S. patent 5,719,148. February 17, 1998.

4. P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity

5. Species differences in N-glucuronidation;Chiu;Drug Metab Dispos,1998

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