Estimation of contribution of CYP2D6 to tipepidine metabolism in humans and prolongation of the half-life of tipepidine by combination use with a CYP2D6 inhibitor in chimeric mice with humanised liver-Reference-Cited by-同舟云学术

Estimation of contribution of CYP2D6 to tipepidine metabolism in humans and prolongation of the half-life of tipepidine by combination use with a CYP2D6 inhibitor in chimeric mice with humanised liver

Published:2023-04-03 Issue:4 Volume:53 Page:241-247
ISSN:0049-8254
Container-title:Xenobiotica
language:en
Short-container-title:Xenobiotica

Author:

Hayashi Shun¹²,Kawaguchi Hiroko¹,Watanabe Takao³,Miyawaki Izuru¹,Fukami Tatsuki²⁴,Nakajima Miki²⁴

Affiliation:

1. Preclinical Research Unit, Drug Research Division, Sumitomo Pharma Co., Ltd, Osaka, Japan

2. Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan

3. Drug Research Division, Sumitomo Pharma Co., Ltd, Osaka, Japan

4. WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kanazawa, Japan

Publisher

Informa UK Limited

Subject

Health, Toxicology and Mutagenesis,Pharmacology,Toxicology,Biochemistry,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/00498254.2023.2224863

Reference33 articles.

1. Expression of Hepatic Drug-Metabolizing Cytochrome P450 Enzymes and Their Intercorrelations: A Meta-Analysis

2. Efficacy and safety of tipepidine as adjunctive therapy in children with attention‐deficit/hyperactivity disorder: Randomized, double‐blind, placebo‐controlled clinical trial

3. Paroxetine for the treatment of depression: a critical update

4. Investigation of Drug-Drug Interactions Caused by Human Pregnane X Receptor-Mediated Induction of CYP3A4 and CYP2C Subfamilies in Chimeric Mice with a Humanized Liver

5. Dose-Dependent Inhibition of CYP2D6 by Bupropion in Patients With Depression

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