A Physiological-Based Pharmacokinetic Model Embedded with a Target-Mediated Drug Disposition Mechanism Can Characterize Single-Dose Warfarin Pharmacokinetic Profiles in Subjects with Various<i>CYP2C9</i>Genotypes under Different Cotreatments-Reference-Cited by-同舟云学术

A Physiological-Based Pharmacokinetic Model Embedded with a Target-Mediated Drug Disposition Mechanism Can Characterize Single-Dose Warfarin Pharmacokinetic Profiles in Subjects with VariousCYP2C9Genotypes under Different Cotreatments

Published:2022-11-15 Issue:2 Volume:51 Page:257-267
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

Cheng Shen,Flora Darcy R.,Rettie Allan E.,Brundage Richard C.^ORCID,Tracy Timothy S.

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

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4. Mechanistic Basis of Using Body Size and Maturation to Predict Clearance in Humans

5. General Pharmacokinetic Features of Small-Molecule Compounds Exhibiting Target-Mediated Drug Disposition (TMDD): A Simulation-Based Study;Bach;J Clin Pharmacol,2019

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