Physiologically‐Based Pharmacokinetic Model of Sertraline in Human to Predict Clinical Relevance of Concentrations at Target Tissues
Author:
Affiliation:
1. Oncology Clinical Pharmacology Pfizer Inc. San Diego California USA
2. Department of Experimental and Clinical Pharmacology University of Minnesota Minneapolis Minnesota USA
Publisher
Wiley
Subject
Pharmacology (medical),Pharmacology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.1824
Reference50 articles.
1. Physiologically Based Pharmacokinetic Modeling and Simulation in Pediatric Drug Development
2. US Food and Drug Administration Physiologically Based Pharmacokinetic Analyses – Format and Content Guidance for Industry (draft) (2016).
3. European Medicines Agency.Guideline on the qualification and reporting of physiologically based pharmacokinetic (PBPK) modelling and simulation (2016).
4. PBPK modeling and simulation in drug research and development
5. Quantitative Prediction of Drug–Drug Interactions Involving Inhibitory Metabolites in Drug Development: How Can Physiologically Based Pharmacokinetic Modeling Help?
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