IDENTIFICATION OF CRITICAL AMINO ACID RESIDUES OF HUMAN CYP2A13 FOR THE METABOLIC ACTIVATION OF 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE, A TOBACCO-SPECIFIC CARCINOGEN-Reference-Cited by-同舟云学术

IDENTIFICATION OF CRITICAL AMINO ACID RESIDUES OF HUMAN CYP2A13 FOR THE METABOLIC ACTIVATION OF 4-(METHYLNITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE, A TOBACCO-SPECIFIC CARCINOGEN

Published:2004-08-27 Issue:12 Volume:32 Page:1516-1521
ISSN:0090-9556
Container-title:Drug Metabolism and Disposition
language:en
Short-container-title:Drug Metab Dispos

Author:

He Xiao-Yang,Shen Jian,Ding Xinxin,Lu Anthony Y. H.,Hong Jun-Yan

Publisher

American Society for Pharmacology & Experimental Therapeutics (ASPET)

Subject

Pharmaceutical Science,Pharmacology

Reference28 articles.

1. Characterization of Cytochrome P450 2A4 and 2A5-Catalyzed 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) Metabolism

2. Predicting the mutagenicity of tobacco-relatedN-nitrosamines in humans using 11 strains ofSalmonella typhimurium YG7108, each coexpressing a form of human cytochrome P450 along with NADPH-cytochrome P450 reductase

3. Identification of Val117 and Arg372 as critical amino acid residues for the activity difference between human CYP2A6 and CYP2A13 in coumarin 7-hydroxylation

4. Biochemistry, Biology, and Carcinogenicity of Tobacco-Specific N-Nitrosamines

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